Rationale for angiotensin II receptor blocker therapy in chronic heart failure
نویسندگان
چکیده
منابع مشابه
[Angiotensin II receptor blocker add-on therapy for low cardiac output in decompensated heart failure].
BACKGROUND During heart failure (HF) decompensation, an intense activation of the renin-angiotensin-aldosterone system occurs; however, the use of angiotensin-converting enzyme inhibitor (ACEI) cannot block it completely. Otherwise, the addition of angiotensin II receptor blocker (ARB) can be useful when the inotropic dependence occurs. We evaluated the efficacy of the ARB-ACEI association on d...
متن کاملAcute effects of angiotensin II receptor blocker on ventricular repolarization alternans in chronic heart failure.
Repolarization alternans, which can be detected clinically as microvolt-level T-wave alternans (TWA), is considered an important mechanism underlying the initiation of ventricular tachycardia/ventricular fibrillation (VT/VF) linked to sudden cardiac death (SCD). Recently, the rennin-angiotensin system (RAS) inhibitors have been suggested to have potential benefits in reducing SCD as well as hea...
متن کاملAre angiotensin II receptor blockers indicated in chronic heart failure?
Chronic heart failure is one of the most serious cardiac problems encountered in clinical practice. Modulation of the renin angiotensin system is a key element in the treatment of this syndrome. There is overwhelming evidence in favour of the benefit of angiotensin converting enzyme (ACE) inhibitors on morbidity and mortality in mild to severe heart failure and in heart failure or left ventricu...
متن کامل[Addition of an angiotensin II receptor blocker to maximal dose of ACE inhibitors in heart failure].
In heart failure, the benefits of adding angiotensin-receptor blockade to ACE inhibitors have been studied only with submaximal doses of ACE inhibitors. We included 20 patients (LVEF 24 7%, NYHA II-III), with no clinical or therapeutic variations in the previous three months, who were receiving maximal doses of ACE inhibitors. We added losartan 50 mg once a day. At six months, SBP decreased (11...
متن کاملA randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure.
BACKGROUND Actions of angiotensin II may contribute to the progression of heart failure despite treatment with currently recommended drugs. We therefore evaluated the long-term effects of the addition of the angiotensin-receptor blocker valsartan to standard therapy for heart failure. METHODS A total of 5010 patients with heart failure of New York Heart Association (NYHA) class II, III, or IV...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the Renin-Angiotensin-Aldosterone System
سال: 2000
ISSN: 1470-3203,1752-8976
DOI: 10.3317/jraas.2000.055